Endocrine Abstracts

Introduction: Pituitary apoplexy (PA) is a rare incident defined by the occurrence of necrosis and/or haemorrhage of the pituitary gland. PA is a clinical syndrome characterized by the sudden onset of headache, vomiting, visual impairment and decreased consciousness in some cases. The objectives of our study are to describe its clinical features and characterize the visual impairments in a cohort of PA in the region of Sfax.Methods: It is a retrospective...

Introduction: Mitochondrial diabetes (MD) is characterized by a broad spectrum of phenotypic and genotypic involvement. Through a cohort study of 40 patients with DM, we tried to correlate this diversity of phenotypic expression with the biomolecular substratum of the mitochondrial genome in the Tunisian population.Results: Epidemiologically and anthropometrically, our series fits the literature data with age at 31.6 years (5–52), female predominanc...

Diabetes is a factor favoring infections. Among which, the sepsis that becomes formidable and serious on this ground. The purpose of our work is to study the clinical, therapeutic and evolutionary features of sepsis in diabetics. A retrospective study of 43 cases of septicemia in diabetic patients collected at the service of Sfax Infectious Diseases. There were 22 men and 21 women, mean age 59 (20–78) years. Community origin was present in 88.4% of cases and nosocomial in...

Introduction: Primary amyloidosis is a multi-systemic disease difficult to identify given the diversity of the disorders that it can cause especially at an early stage of the disease. This makes its diagnosis difficult in case of association with a pathology that can be intricate with its clinical expression. In this context we report the first case in the literature associating mitochondrial diabetes (DM) with a primary amyloidosisCase: A 32 years old g...

Introduction: Turner Syndrome (TS) is known to be associated with congenital malformations and a greater incidence of autoimmune disease. Many others organs systems are also affected to varying degrees and at different stages of life such as abnormal liver function. This disease is often detected on routine investigation and is not accompanied by signs or symptoms of liver disease. We report the case of a young Turnerian who presents a disruption of his hepatic balance with a ...

Background: Azoospermia is present at approximately 1% of the man. karyotype can show number and structure abnormalities of the sexe chromosomes.Case: 16 years old boy,who was refered to the departement of endocrinology for a failure to growth since 8 years old. This patient was resulting from a marriage between blood relations. He had a congenital bilateral hip luxation diagnosed since birth but untreated.He had a gait disorder with a low weight 32 kg &...

Introduction: Deficiency of 17-βHSD3 is a rare autosomal recessive disorder of sex development manifesting in XY karyotype individuals. The presentation can range from partial or incomplete virilisation at birth to primary amenorrhoea and virilisation at puberty of an externally phenotypically female individual.Case reports: Case1 A 2-year-old girl presented with ambiguity of external genetalia. She had no significant past medical or surgical histor...

Introduction: Congenital hypothyroidism (CH) is the most common congenital endocrine disease since it affects 1/3000–1/4000 births. The involvement of genetics is no longer discussed and several genes have been implied in the different clinical forms of thyroid dysgenesis.Patients and methods: We report ten cases of thyroid dysgenesis collected at the pediatric and endocrinology departments of Sfax in Tunisia. The diagnosis was based on clinical, bi...

Imipenem (IMP) is a carbapenem antibiotic mainly used to treat nosocomial infection diseases. We aimed to evaluate the oxidative stress of therapeutic doses of imipenem (IMP) on the ovary of ‘wistar’ rats. In this respect, female rats were divided into four groups: animals were intraperitoneally treated with physiological serum, 30, 50 and 80 mg/kg of IMP for one week. We found that therapeutic doses of this drug did not significantly affect the levels of ovarian mal...

IntroductionThe thresholds of late night salivary cortisol (LNSC) vary widely among studies due to differences in assay methodologies and in control groups. We aimed to verify the analytical performance of the LNSC by electrochimiluminescence assay (ECLIA) and to establish cut-off values of LNSC for the screening of Cushing’s syndrome (CS).MethodsPatients with suspected CS underwent screening tests inclu...